Darrin, thanks for sending in that question. The simple answer is yes, there are differences between the two.
There are actually several types of lightning including cloud-to-cloud, cloud-to-ground, dark lightning, and several variations.
Cloud-to-cloud lightning happens when lightning strikes happen between two clouds or several clouds. You still shouldn't be outside, but it's not as dangerous.
Cloud-to-ground lightning is the most dangerous. It poses the greatest threat to life and property because the lightning goes from the cloud and strikes something on the ground.
Cloud-to-cloud lightning isn't as harmful, but should still be taken seriously.